
Best Alpha Arbutin Manufacturers | Supplier with Wholesale Price - Greenway Biotech
Arbutin is a hydroquinone glycoside compound, the chemical name is 4-Hydroquinone-alpha-D-glucopyranoside, which exists in bearberry, bilberry and other plants. It is a new non-irritating, non-allergic and highly compatible natural whitening active substance from Chemicalbook. There are two structural and functional functional groups in the molecular structure of arbutin: one is a glucose residue; the other is a phenolic hydroxyl group. The physical state of α-arbutin is white to light gray powder, which is easily soluble in water and ethanol.
Product Name | Alpha Arbutin |
English synonyms | Alpha Arbutin Powder; 4-hydroquinone-alpha-d-glucopyranoside; alpha-arbutin; a-Arbutin; HydroquinoneO-alpha -D-Glucopyranoside; 4-Hydroxyphenyla-D-gChemicalbooklucopyranoside;(2R,3S,4S,5R,6S)-2-(HYDROXYMETHYL)-6-(4-HYDROXYPHENOXY)TETRAHYDROPYRAN-3,4,5-TRIOL;4-hydroxyphenylalpha-D-glucopyranoside |
Molecular formula: | C12H16O7 |
Molecular weight: | 272.25 |
EC Number | 209-795-0 |
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Melting point | 195-196°C |
Boiling point | 561.6±50.0°C(Predicted) |
Density | 1.556±0.06g/cm3(Predicted) |
Storage conditions | 2-8°C |
Solubility | DMSO(Slightly),Methanol(Slightly) |
Appearance | Solid |
Color | White to Off-White |
Effect | α-Arbutin has a good therapeutic effect on scars caused by ultraviolet burns, and has good anti-inflammatory, repairing and whitening effects. Can inhibit the production and deposition of melanin, remove pigmentation and freckles. |
Mechanism | The whitening mechanism of α-arbutin directly inhibits the activity of tyrosinase, thereby reducing the production of melanin, rather than reducing the production of melanin by inhibiting cell growth or tyrosinase gene expression. Since α-arbutin is a more efficient and safer whitening active substance, many cosmetic companies at home and abroad have used α-arbutin instead of β-arbutin as a whitening additive. |
Application | Alpha-arbutin is a chemical, similar to arbutin, that inhibits the production and deposition of melanin, and removes pigmentation and freckles. Studies have shown that arbutin can inhibit the activity of tyrosinase at a relatively low concentration, and its inhibitory effect on tyrosinase is better than that of arbutin. Alpha-arbutin can be used in cosmetics as a whitening agent. |
Purification and Identification | The samples obtained by the reaction were first extracted with ethyl acetate, then extracted with n-butanol, evaporated to dryness by a rotary evaporator, and then centrifuged. The supernatant was analyzed by HPLC and compared with α-arbutin standard Compare the HPLC chromatogram of the product, compare whether the sample and α-arbutin have the same retention time of Chemicalbook, and preliminarily infer whether the sample contains α-arbutin. The product after extraction and purification was identified by the positive ion mode of LC-ESI-MS/MS. The relative molecular mass of the α-arbutin product is compared with the relative molecular weight of the α-arbutin standard to determine whether the product is α-arbutin. |
Items | Specifications | Results |
Appearance | White or Off-white Powder | White Powder |
pH value | 5.0-7.0 | 6.05 |
Melting point | 202℃-210℃ | 204.8℃-205.6℃ |
Specific optical rotation | +175.0°~+185.0° | +179.4° |
Loss on drying | ≤1.0% | 0.13% |
Transmittance | ≥95.0% | 99.0% |
Hydroquinone(HPLC) | 10ppm | <10ppm |
Heavy metals | ≤10ppm | <10ppm |
Arsenic | ≤2ppm | <2ppm |
Lead(Pb) | ≤1ppm | <1ppm |
Residue on ignition | ≤0.5% | 0.05% |
Assay(HPLC) | ≥99.5% | 99.98% |
Total plate count | ≤1000 CFU/g | 20CFU/g |
Yeast&Mold | ≤100 CFU/g | 10CFU/g |
E.Coli | Not detectable | Not detectable |
Staphylococcus aureus | Not detectable | Not detectable |
Pseudonmonas aeruginosa | Not detectable | Not detectable |
Conclusion | The product conforms to standard of Q/AHH012 |
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Certificate of Analysis | Alpha Arbutin Powder
Product Info | Alpha Arbutin